ALOE SOCOTRINA (Mussabbar)

Botanical: Aloe Perryi (J. G. BAKER), Aloe vera (LINN)
Family: N.O. Liliaceae

• ---Part Used--
  

The inspissated juice of the leaves of one or more undetermined species, commonly known as Socotrine Aloes. It is in masses of a reddish-brown colour, the varying shades deepening by exposure to the air. It is nearly transparent in thin films. Its fracture, usually smooth and resinous, is sometimes rough and irregular. It has a speculiarly strong and fragrant odour and an intensely bitter taste. It is almost entirely soluble in alcohol and sparingly in water. While dissolving in alcohol it exhibits microscopic crystals. For the preparation of tincture use the inspissated juice, coarsely pulverized.


Latin, Aloe gummi, A. lucida, A. Officinalis, A. ruboscens, A. spicata, A. vera ; English, Hepatic, Mocha, Moka or Socotrina aloes ; French, Aloes ; German, Aloe ; Arabic, Mussabbar; Urdu, Mussabbar
---Habitat---Aloes are indigenous to East and South Africa, but have been introduced into the West Indies (where they are extensively cultivated) and into tropical countries, and will even flourish in the countries bordering on the Mediterranean.

The drug Aloes consists of the liquid exuded from the transversely-cut bases of the leaves of various species of Aloes, evaporated to dryness.

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---Description---They are succulent plants belonging to the Lily family, with perennial, strong and fibrous roots and numerous, persistent, fleshy leaves, proceeding from the upper part of the root, narrow, tapering, thick and fleshy, usually beset at the edges with spiney teeth. Many of the species are woody and branching. In the remote districts of S.W. Africa and in Natal, Aloes have been discovered 30 to 60 feet in height, with stems as much as 10 feet in circumference.

The flowers are produced in erect, terminal spikes. There is no calyx, the corolla is tubular, divided into six narrow segments at the mouth and of a red, yellow or purplish colour. The capsules contain numerous angular seeds.

The true Aloe is in flower during the greater part of the year and is not to be confounded with another plant, the Agave or American Aloe (Agave Americana), which is remarkable for the long interval between its periods of flowering. This is a succulent plant, without stem, the leaves being radical, spiney, and toothed. There is a variety with variegated foliage. The flower-stalk rises to many feet in height, bearing a number of large and handsome flowers. In cold climates there is usually a very long interval between the times of its flowering, though it is a popular error to suppose that it happens only once in a hundred years for when it obtains sufficient heat and receives a culture similar to that of the pineapple, it is found to flower much more frequently. Various species of Agave, all of which closely resemble each other, have been largely grown as ornamental plants since the first half of the sixteenth century in the south of Europe, and are completely acclimatized in Spain, Portugal and Southern Italy, but though often popularly called Aloes all of them are plants of the New World whereas the true Aloes are natives of the Old World. From a chemical point of view there is also no analogy at all between Aloes and Agaves.

Although the Agave is not employed medicinally, the leaves have been used in Jamaica as a substitute for soap, the expressed juice (a gallon of the juice yields about 1 lb. of the soft extract), dried in the sun, being made into balls with wood ash. This soap lathers with salt water as well as fresh. The leaves have also been used for scouring pewter and kitchen utensils. The inner spongy substance of the leaves in a decayed state has been employed as tinder and the fibres may be spun into a strong, useful thread.

The fleshy leaves of the true Aloe contain near the epidermis or outer skin, a row of fibrovascular bundles, the cells of which are much enlarged and filled with a yellow juice which exudes when the leaf is cut. When it is desired to collect the juice, the leaves are cut off close to the stem and so placed that the juice is drained off into tubs. This juice thus collected is concentrated either by spontaneous evaporation, or more generally by boiling until it becomes of the consistency of thick honey. On cooling, it is then poured into gourds, boxes, or other convenient receptacles, and solidifies.

Aloes require two or three years' standing before they yield their juice. In the West Indian Aloe plantations they are set out in rows like cabbages and cutting takes place in March or April, but in Africa the drug is collected from the wild plants.

---Constituents---The most important constituents of Aloes are the two Aloins, Barbaloin and Isobarbaloin, which constitute the so-called 'crystalline' Aloin, present in the drug at from 10 to 30 per cent. Other constituents are amorphous Aloin, resin and Aloe-emodin. The proportion in which the Aloins are present in the respective Aloes is not accurately known.

The manner in which the evaporation is conducted has a marked effect on the appearance of the Aloes, slow and moderate concentration tending to induce crystallization of the Aloin, thus causing the drug to appear opaque. Such Aloes is termed 'livery' or hepatic, and splinters of it exhibit minute crystals of Aloin when examined under the microscope. If, on the other hand, the evaporation is carried as far as possible, the Aloin does not crystallize and small fragments of the drug appear transparent; it is then termed 'glassy,' 'vitreous,' or 'lucid' Aloes and exhibits no crystals of Aloin under the microscope.

---Varieties---The chief varieties of Aloes are Curacao or Barbados, Socotrine (including Zanzibar) and Cape. Other varieties of Aloes, such as black 'Mocha' Aloes, occasionally find their way to the London market. Jafferabad Aloes, supposed to be the same as 'Mocha' Aloes, is of a black, pitch-like colour and a glassy, somewhat porous fracture; it is the product of Aloe Abyssinica and is imported to Bombay from Arabia. It does not enter into English commerce. Musambra Aloes is made in India from A. vulgaris. Uganda Aloes, imported from Mossel Bay, not from Uganda, is a variety of Cape Aloes produced by careful evaporation. Natal Aloes, another South African variety, is no longer a commercial article in this country. The A. Purificata of the United States Pharmacopoeia is prepared by adding Alcohol to melted Aloes, stirring thoroughly, straining and evaporating the strained liquid. The product occurs in irregular, brittle, dull- brown or reddish pieces and is almost entirely soluble in Alcohol.

Curacoa Aloes is obtained from A. chinensis (Staud.) A. vera (Linn.) and probably other species. It was formerly produced on the island of Barbados, where it was largely cultivated, having been introduced at the beginning of the sixteenth century, and is still frequently, but improperly called Barbados Aloes. It is now almost entirely made on the Dutch islands of Curacoa, Aruba and Bonaire by boiling the Aloe juice down and pouring the viscid residue into empty spirit cases, in which it is allowed to solidify. Formerly gourds of various sizes were used (usually containing from 60 to 70 lb.) but Aloes in gourds is now seldom seen. It is usually opaque and varies in colour from bright yellowish or rich reddish brown to black. Sometimes it is vitreous and small fragments are then of a deep garnet-red colour and transparent. It is then known as 'Capey Barbados' and is less valuable, but may become opaque and more valuable by keeping. Curacoa Aloes possesses the nauseous and bitter taste that is characteristic of all Aloes and a disagreeable, penetrating odour. It is almost entirely soluble in 60 per cent alcohol and contains not more than 30 per cent of substances insoluble in water and 12 per cent of moisture. It should not yield more than 3 per cent of ash.

Commercial Aloin is obtained usually from Curacoa Aloes.

Solutions of Curacoa and other Aloes gradually undergo change, and may after a month no longer react normally, and may also lose the bitterness natural to Aloes.

Socotrine Aloes is prepared to a certain extent on the island of Socotra, but probably more largely on the African and possibly also on the Arabian mainland, from the leaves of A. Perryi (Baker). It is usually imported in kegs in a pasty condition and subsequent drying is necessary. It may be distinguished principally from Curacoa Aloes by its different odour. Much of the dry drug is characterized by the presence of small cavities in the fractured surface, but the variety of Socotrine Aloes distinguished as Zanzibar Aloes often very closely resembles Curacoa in appearance and is usually imported in liver-brown masses which break with a dull, waxy fracture, differing from that of Socotrine Aloes in being nearly smooth and even. When it is prepared, it is commonly poured into goat skins, which are then packed into cases.

---Constituents---The name 'Socotrine' Aloes is officially applied to both Socotrine and Zanzibar Aloes. Its chief constituents are Barbaloin (formerly called Socaloin and Zanaloin) and B. Barbaloin, no Isobarbaloin being present in this variety of Aloes. Resin water-soluble substances other than Aloin and Aloe-emodin are also present.

Socotrine Aloes should be of a dark, reddish-brown colour, and almost entirely soluble in alcohol. Not more than 50 per cent should be insoluble in water and it should yield not more than 3 per cent of ash. Garnet-coloured, translucent Socotrine Aloes is not now found in commerce, though fine qualities of Zanzibar Aloes are sometimes slightly translucent. Samples of the drug which are nearly black are unfit for pharmaceutical purposes. The odour of Zanzibar Aloes is strong and characteristic, and its taste nauseous and bitter.

Cape Aloes is prepared in Cape Colony from A. ferou (Linn.), A. spicata (Thumb.) A. Africana, A. platylepia and other species of Aloe. It possesses more powerfully purgative properties than any other variety of the drug and is preferred to other varieties on the Continent, but is chiefly employed in this country for veterinary purposes only though for this purpose the Curacoa Aloes is as a rule preferred. Another form of the drug used for veterinary purposes, called Caballine or Horse Aloes, usually consists of the residue from the purification of the more valuable sorts.

Cape Aloes almost invariably occurs in the vitreous modification; it forms dark coloured masses which break with a clean glassy fracture and exhibit in their splinters a yellowish, reddish-brown or greenish tinge. Its translucent, glossy appearance and very characteristic, red-currant like odour sufficiently distinguish it from all other varieties of Aloes.

Uganda Aloes is also obtained from A. ferox. It occurs in bricks or fragments of hepatic, yellowish-brown colour, with a bronze gold fracture and its odour resembles that of Cape Aloes.

Cape Aloes contains 9 per cent or more of Barbaloin (formerly known as Capaloin) and B. Barbaloin. Only traces of Capalores not annol combined with paracumaric acid. Cape Aloes should not contain more than 12 per cent of water; it should yield at least 45 per cent of aquoeus extract but not more than 2 per cent of ash Uganda Aloes yields about 6 per cent of Aloin, part of which is B. Barbaloin. The leaves of the plants from which Cape Aloes is obtained are cut off near the stem and arranged around a hole in the ground, in which a sheepskin is spread, with smooth side upwards. When a sufficient quantity of juice has drained from the leaves it is concentrated by heat in iron cauldrons and subsequently poured into boxes or skins in which it solidifies on cooling. Large quantities of the drug are exported from Cape Town and Mossel Bay.

Natal Aloes. The source of this variety which is seldom imported, is not yet definitely ascertained, but it is probably prepared from one or more species of Aloe, probably including A. ferox. Natal Aloes is prepared with greater care than Cape Aloes the leaves being cut obliquely into slices and the juice allowed to exude in the hot sunshine, after which it is boiled down in iron pots the liquid being stirred until it becomes thick and then poured into wooden cases to solidify. Natal Aloes is much weaker than any other variety, having little purgative action on human beings, apparently because it contains no Emodin. It is no longer of commercial importance. It resembles Cape Aloes in odour and occurs in irregular pieces which are almost always opaque and have a characteristic, dull greenish-black or brown colour. It is much less soluble than Cape Aloes. It has not a glassy fracture like that of Cape Aloes and when powdered is of a greenish colour.

Good Aloes should yield 40 per cent of soluble matter to cold water.

Both Curacoa and Cape Aloes in powder give a crimson colour with nitric acid, Socratine Aloes powder touched with nitric acid does not give a crimson colour.

---History---The Mahometans, especially those in Egypt, regard the Aloe as a religious symbol, and the Mussulman who has made a pilgrimage to the shrine of the Prophet is entitled to hang the Aloe over his doorway. The Mahometans also believe that this holy symbol protects a householder from any malign influence.

In Cairo, the Jews also adopt the practice of hanging up the Aloe.

In the neighbourhood of Mecca, at the extremity of every grave, on a spot facing the epitaph, Burckhardt found planted a low shrubby species of Aloe whose Arabic name, saber, signifies patience. This plant is evergreen and requires very little water. Its name refers to the waiting-time between the burial and the resurrection morning.

All kinds of Aloes are admirably provided by their succulent leaves and stems against the drought of the countries where they flourish. The cuticle which covers every part of the plant is, in those which contain a great quantity of pulpy material, formed so as to imbibe moisture very easily and to evaporate it very slowly. If the leaf of an Aloe be separated from the parent plant, it may be laid in the sun for several weeks without becoming entirely shrivelled; and even when considerably dried by long exposure to heat, it will, if plunged into water, become in a few hours plump and fresh.

---Medicinal Action and Uses---The drug Aloes is one of the safest and best warm and stimulating purgatives to persons of sedentary habits and phlegmatic constitutions. An ordinary small dose takes from 15 to 18 hours to produce an effect. Its action is exerted mainly on the large intestine, for which reason, also it is useful as a vermifuge. Its use, however, is said to induce Piles.

From the Chemist and Druggist (July 22, 1922):

'Aloes, strychnine and belladonna in pill form was criticized by Dr. Bernard Fautus in a paper read before the Chicago branch of the American Pharmaceutical Society. He pointed out that when given at the same time they cannot possibly act together because of the different speed and duration of the three agents. Aloin is slow in action, requiring from 10 to 12 hours. Strychnine and Atropine, on the other hand, are rapidly absorbed, and have but a brief duration of action.'

Preparations of Aloes are rarely prescribed alone, they require the addition of carminatives to moderate the tendency to griping. The compound preparations of Aloes in use generally contain such correctives, but powdered Aloes and the extracts of Aloes represent the crude drug.

Aloes in one form or another is the commonest domestic medicine and is the basis of most proprietary or so-called 'patent' pills.

There is little to choose medicinally between the Curacoa and Socotrine varieties, but the former is somewhat more powerful, 2 grains of Curacoa Aloes being equal to 3 grains of Socotrine Aloes in purgative action. The latter is more expensive, but varies much in quality.

Aloes is the purgative in general uses for horses, it is also used in veterinary practice as a bitter tonic in small doses, and externally as a stimulant and desiccant.

Aloes was employed by the ancients and was known to the Greeks as a production of the island of Socotra as early as the fourth century B.C. The drug was used by Dioscorides, Celsus and Pliny, as well as by the later Greek and Arabian physicians, though it is not mentioned either by Hippocrates or Theophrastus.

From notices of it in the Anglo-Saxon leech-books and a reference to it as one of the drugs recommended to Alfred the Great by the Patriarch of Jerusalem, we may infer that its use was not unknown in Britain as early as the tenth century. At this period the drug was imported into Europe by way of the Red Sea and Alexandria. In the early part of the seventeenth century, there was a direct trade in Aloes between England and Socotra, and in the records of the East Indian Company there are notices of the drug being bought of the King of Socotra, the produce being a monopoly of the Sultan of the island.

The word Aloes, in Latin Lignum Aloes, is used in the Bible and in many ancient writings to designate a substance totally distinct from the modern Aloes, namely the resinous wood of Aquilaria agallocha, a large tree growing in the Malayan Peninsula. Its wood constituted a drug which was, down to the beginning of the present century, generally valued for use as incense, but now is esteemed only in the East.

A beautiful violet colour is afforded by the leaves of the Socotrine Aloe, and it does not require a mordant to fix it.

(a)Tincture Q: = Drug Strength 1/10 Aloe, in moderately coarse powder. 100gm. Strong alcohol, a sufficient quantity . To make one thousand cubic centimeters of tincture. (b) Dilutions: 2x and higher with dispensing alcohol. (c) Triturations: 2x and higher.

Aconite nap

Botanical: Aconitum napellus (LINN.)
Family: N.O. Ranunculaciae

• Description
• Cultivation
• Part Used
• Chemical Constituents
• Medicinal Action and Uses
• Poisoning from, and Antidotes
• Other Varieties
• Other Species

---Synonyms---Monkshood. Blue Rocket. Friar's Cap. Auld Wife's Huid.
---Part Used---The whole plant.
---Habitat---Lower mountain slopes of North portion of Eastern Hemisphere. From Himalayas through Europe to Great Britain.

Aconite is now found wild in a few parts of England, mainly in the western counties and also in South Wales, but can hardly be considered truly indigenous. It was very early introduced into England, being mentioned in all the English vocabularies of plants from the tenth century downwards, and in Early English medical recipes.

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---Description---The plant is a hardy perennial, with a fleshy, spindle-shaped root, palecoloured when young, but subsequently acquiring a dark brown skin. The stem is about 3 feet high, with dark green, glossy leaves, deeply divided in palmate manner and flowers in erect clusters of a dark blue colour. The shape of the flower is specially designed to attract and utilize bee visitors, especially the humble bee. The sepals are purple - purple being specially attractive to bees - and are fancifully shaped, one of them being in the form of a hood. The petals are only represented by the two very curious nectaries within the hood, somewhat in the form of a hammer; the stamens are numerous and lie depressed in a bunch at the mouth of the flower. They are pendulous at first, but rise in succession and place their anthers forward in such a way that a bee visiting the flower for nectar is dusted with the pollen, which he then carries to the next flower he visits and thereby fertilizes the undeveloped fruits, which are in a tuft in the centre of the stamens, each carpel containing a single seed.

In the Anglo-Saxon vocabularies it is called thung, which seems to have been a general name for any very poisonous plant. It was then called Aconite (the English form of its Greek and Latin name), later Wolf's Bane, the direct translation of the Greek Iycotonum, derived from the idea that arrows tipped with the juice, or baits anointed with it, would kill wolves - the species mentioned by Dioscorides seems to have been Aconitum lycotonum. In the Middle Ages it became Monkshood and Helmet-flower, from the curious shape of the upper sepal overtopping the rest of the flower. This was the ordinary name in Shakespeare's days.

The generic name is said to have been derived from < i="">, a dart, because it was used by barbarous races to poison their arrows, or from akone, cliffy or rocky, because the species grow in rocky glens. Theophrastus, like Pliny, derived the name from Aconae, the supposed place of its origin. The specific name, Napellus, signifies a little turnip, in allusion to the shape of the roots. <>

---Cultivation---The chief collecting centres for foreign Aconite root have been the Swiss Alps, Salzburg, North Tyrol and Vorarlberg. Much was also formerly collected in Germany. Supplies from Spain and Japan are imported, so that the demand for English Aconite is somewhat restricted. The official Aconite is directed by the British Pharmacopceia to be derived only from plants cultivated in England, and a certain amount of home-grown Aconite has been regularly produced by the principal drug-farms, though good crops are grown with some difficulty in England, and cultivation of Aconite has not paid very well in recent years.

Aconite prefers a soil slightly retentive of moisture, such as a moist loam, and flourishes best in shade. It would probably grow luxuriantly in a moist, open wood, and would yield returns with little further trouble than weeding, digging up and drying.

In preparing beds for growing Aconite, the soil should be well dug and pulverized by early winter frosts - the digging in of rotten leaves or stable manure is advantageous.

It can be raised from seed, sown 1/2 inch deep in a cold frame in March, or in a warm position outside in April, but great care must be exercised that the right kind is obtained, as there are many varieties of Aconite- about twenty-four have been distinguished - and they have not all the same active medicinal properties. It takes two or three years to flower from seed.

Propagation is usually by division of roots in the autumn. The underground portion of the plants are dug up after the stem has died down, and the smaller of the 'daughter' roots that have developed at the side of the old roots are selected for replanting in December or January to form new stock, the young roots being planted about a foot apart each way. The young shoots appear above ground in February. Although the plants are perennial, each distinct root lasts only one year, the plant being continued by 'daughter' roots.

This official Aconite is also the species generally cultivated in gardens, though nearly all the species are worth growing as ornamental garden flowers, the best perhaps being A. Napellus, both white and blue, A. paniculatum, A. Japonicum and A. autumnale. All grow well in shade and under trees. Gerard grew four species in his garden: A. lyocotonum, A. variegatum, A. Napellus and A. Pyrenaicum.

---Part Used---Collection and Drying. The leaves, stem, flowering tops and root: the leaves and tops fresh, the root dried. The leaves and flowering tops are of less importance, they are employed for preparing Extract of Aconitum, and for this purpose are cut when the flowers are just breaking into blossom and the leaves are in their best condition, which is in June.

The roots should be collected in the autumn, after the stem dies down, but before the bud that is to produce the next year's stem has begun to develop. As this bud grows and forms a flowering stem, in the spring, some of the lateral buds develop into short shoots, each of which produces a long, slender, descending root, crowned with a bud. These roots rapidly thicken, filled with reserve material produced by the parent plant, the root of which dies as the 'daughter' roots increase in size. Towards the autumn, the parent plant dies down and the daughter roots which have then reached their maximum development are now full of starch. If allowed to remain in the soil, the buds that crown the daughter roots begin to grow, in the late winter, and this growth exhausts the strength of the root, and the proportion of both starch and alkaloid it contains is lessened.

On account of the extremely poisonous properties of the root, it is considered desirable that the root should be grown and collected under the same conditions, so that uniformity in the drug is maintained. The British Pharmacopceia specifies, therefore, that the roots should be collected in the autumn from plants cultivated in Britain and should consist of the dried, full-grown 'daughter' roots: much of the Aconite root that used to come in large quantities from Germany was the exhausted parent root of the wild-flowering plants.

When the roots are dug up, they are sorted over, the smallest laid aside for replanting and the plumper ones reserved for drying. They are first well washed in cold water and trimmed of all rootlets, and then dried, either entire, or longitudinally sliced to hasten drying.

Drying may at first be done in the open air, spread thinly, the roots not touching. Or they may be spread on clean floors or on shelves in a warm place for about ten days, turning frequently. When somewhat shrunken, they must be finished more quickly by artificial heat in a drying room or shed near a stove or gas fire, care being taken that the heated air can escape at the top of the room. Drying in an even temperature will probably take about a fortnight or more. It is not complete till the roots are dry to the core and brittle, snapping when bent.

Dried Aconite root at its upper extremity, when crowned with an undeveloped bud, enclosed by scaly leaves, is about 3/4 inch in diameter, tapering quickly downwards. It is dark brown in colour and marked with the scars of rootlets. The surface is usually longitudinally wrinkled, especially if it has been dried entire. The root breaks with a short fracture and should be whitish and starchy within. A transverse section shows a thick bark, separated from the inner portion by a well-marked darker line, which often assumes a stellate appearance. Aconite root as found in commerce is, however, often yellowish or brownish internally with the stellate markings not clearly shown, probably from having been collected too early. It should be lifted in the autumn of the second year.

Aconite root is liable to attack by insects, and after being well dried should be kept in securely closed vessels.

---Chemical Constituents---Aconite root contains from 0.3 to 1 per cent alkaloidal matter, consisting of Aconitine - crystalline, acrid and highly toxic - with the alkaloids Benzaconine (Picraconitine) and Aconine.

Aconitine, the only crystallizable alkaloid, is present to the extent of not more than 0.2 per cent, but to it is due the characteristic activity of the root. Aconite acid, starch, etc., are also present. On incineration, the root yields about 3 per cent ash.

The Aconitines are a group of highly toxic alkaloids derived from various species of Aconite, and whilst possessing many properties in common are chemically distinguishable according to the source from which they are obtained. The Aconitines are divided into two groups: (1) the Aconitines proper, including Aconitine, Japaconitine and Indaconitine, and (2) the Pseudaconitines - Pseudaconitine and Bikhaconitine.

This disparity between Aconites is a very important matter for investigation, though perhaps not so serious from a pharmaceutical point of view as might at first appear, since in the roots of several different species the alkaloid is found to possess similar physiological action; but this action varies in degree and the amount of alkaloid may be found to vary considerably. It is considered that the only reliable method of standardizing the potency of any of the Aconite preparations is by a physiological method: the lethal dose for the guinea-pig being considered to be the most convenient and satisfactory standard. Tinctures vary enormously as to strength, some proving seven times as powerful as others.

The Aconite which contains the best alkaloid, A. Napellus, is the old-fashioned, familiar garden variety, which may be easily recognized by its very much cut-up leaves, which are wide in the shoulder of the leaf - that part nearest the stem - and also by the purplish-blue flowers, which have the 'helmet' closely fitting over the rest of the flower, not standing up as a tall hood. All varieties of Aconite are useful, but this kind with the close set in helmet to the flower is the most valuable.

The Aconite derived from German root of A. Napellus appears to possess somewhat different properties to that prepared from English roots. The German roots may be recognized by the remains of the stem which crown the root. They are also generally less starchy, darker externally and more shrivelled than the English root and considered to be less active, probably because they are generally the exhausted parent roots.

---Medicinal Action and Uses---Anodyne, diuretic and diaphoretic. The value of Aconite as a medicine has been more fully realized in modern times, and it now rank as one of our most useful drugs. It is much used in homoeopathy. On account of its very poisonous nature, all medicines obtained from it come, however, under Table 1 of the poison schedule: Aconite is a deadly poison.

Both tincture and liniment of Aconite are in general use, and Aconite is also used in ointment and sometimes given as hypodermic injection. Preparations of Aconitc are employed for outward application locally to the skin to diminish the pain of neuralgia, lumbago and rheumatism.

The official tincture taken internelly diminishes the rate and force of the pulse in the early stages of fevers and slight local inflammations, such as feverish cold, larnyngitis, first stages of pneumonia and erysipelas; it relieves the pain of neuralgia, pleurisy and aneurism. In cardiac failure or to prevent same it has been used with success, in acute tonsilitis children have been well treated by a dose of 1 to 2 minims for a child 5 to 10 years old; the dose for adults is 2 to 5 minims, three times a day.
---Note---The tincture of Aconite of the British Pharmacopoeia 1914 is nearly double the strength of that in the old Pharmacopoeia of 1898.

Externally the linament as such or mixed with chloroform or belladonna liniment is useful in neuralgia or rheumatism.

---Poisoning from, and Antidotes---The symptons of poisoning are tingling and numbness of tongue and mouth and a sensation of ants crawling over the body, nausea and vomiting with epigastric pain, laboured breathing, pulse irregular and weak, skin cold and clammy, features bloodless, giddiness, staggering, mind remains clear. A stomach tube or emetic should be used at once, 20 minims of Tincture of Digitalis given if available, stimulants should be given and if not retained diluted brandy injected per rectum, artificial respiration and friction, patient to be kept lying down.

All the species contain an active poison Aconitine, one of the most formidable poisons which have yet been discovered: it exists in all parts of the plant, but especially in the root. The smallest portion of either root or leaves, when first put into the mouth, occasions burning and tingling, and a sense of numbness immediately follows its continuance. One-fiftieth grain of Aconitine will kill a sparrow in a few seconds; one-tenth grain a rabbit in five minutes. It is more powerful than prussic acid and acts with tremendous rapidity. One hundredth grain will act locally, so as to produce a well-marked sensation in any part of the body for a whole day. So acrid is the poison, that the juice applied to a wounded finger affects the whole system, not only causing pains in the limbs, but a sense of suffocation and syncope.

Some species of Aconite were well known to the ancients as deadly poisons. It was said to be the invention of Hecate from the foam of Cerberus, and it was a species of Aconite that entered into the poison which the old men of the island of Ceos were condemned to drink when they became infirm and no longer of use to the State. Aconite is also supposed to have been the poison that formed the cup which Medea prepared for Theseus. (Note---Aconite and Belladonna were said to be the ingredients in the witches' 'Flying ointments.' Aconite causes irregular action of the heart, and Belladonna produces delirium. These combined symptoms might give a sensation of 'flying.'---EDITOR)

Various species of Aconite possess the same narcotic properties as A. Napellus, but none of them equal in energy the A. ferox of the East Indies, the root of which is used there as an energetic poison under the name of Bikh or Nabee. Aconite poisoning of wells by A. ferox has been carried out by native Indians to stop the progress of an army. They also use it for poisoning spears, darts and arrows, and for destroying tigers.

All children should be warned against Aconite in gardens. It is wiser not to grow Aconite among kitchen herbs of any sort. The root has occasionally been mistaken for horse-radish, with fatal results - it is, however, shorter, darker and more fibrous - and the leaves have produced similar fatal results. In Ireland a poor woman once sprinkled powdered Aconite root over a dish of greens, and one man was killed and another seriously affected by it.

In 1524 and 1526 it is recorded that two criminals, to whom the root was given as an experiment, quickly died.

The older herbalists described it as venomous and deadly. Gerard says: 'There hath beene little heretofore set down concerning the virtues of the Aconite, but much might be saide of the hurts that have come thereby.' It was supposed to be an antidote against other poisons. Gerard tells us that its power was 'So forcible that the herb only thrown before the scorpion or any other venomous beast, causeth them to be without force or strength to hurt, insomuch that they cannot moove or stirre untill the herbe be taken away.' Ben Jonson, in his tragedy Sejanus, says:

'I have heard that Aconite

Being timely taken hath a healing might

Against the scorpion's stroke.'

Linnaeus reports Aconite to be fatal to cattle and goats when they eat it fresh, but when dried it does no harm to horses, a peculiarity in common with the buttercups, to which the Aconites are related. Field-mice are well aware of its evil nature, and in hard times, when they will attack almost any plant that offers them food, they leave this severely alone.

---Other Varieties---Japanese Aconite - syn. Aconitum Chinense - is regularly imported in considerable quantities. It used formerly to be ascribed to A. Fischer (Reichb.), but is now considered to be derived from A. uncinatum, var. Faponicum (Regel.) and possibly also from A. volubile (Pallas). It has conical or top-shaped, gradually tapering tuberous roots, 1 to 2 inches long, 1/3 to 1 inch in thickness at the top, externally covered with a brown, closely adhering skin internally white. Dried roots do not contain much alkaloid, if steeped when fresh in a mixture of common salt, vinegar and water. The poisonous alkaloid present is called Japaconitine, to distinguish it from the official Aconitine and the Pseudaconitine of A. laciniatum. Japaconitine is similar in constituents and properties with the Aconitine of A. Napellus.

Indian Aconite root or Nepal Aconite consists of the root of A. laciniatum (Staph.). It is also called Bikh or Bish, and is collected in Nepal. It is much larger than the English variety, being a conical, not suddenly tapering root, 2 to 4 inches long and an inch or more at the top, of a lighter brown than the official variety, the rootlet scars much fewer than the official root. Internally it is hard and almost resinous, the taste intensely acrid and is much shriveiled longitudinally. This root yields a very active alkaloid, Pseudoaconitine, which is allied to Aconitine and resembles it in many of its properties; it is about twice as active as Aconitine. Indian Aconite root was formerly attributed to A. ferox (Wall). Their large size and less tapering character sufficiently distinguish these from the official drug.

Other varieties of Aconite are A. chasmanthum (Staph.), known in India as Mohri, which contains Indaconitine, and A. spicatum, another Indian species containing Bikhaconitine, resembling Pseudaconitine.

Russian Aconite, A. orientale, grows abundantly in the Crimea and Bessarabia. It has a small, compact, greyish-black root with a transverse section similar to that of A. Napellus. Its taste is hot and acrid. When treated by a process which gave 0.0526 per cent of crystalline Aconitine from a sample of powdered root of A. Napellus, the dried root of A. orientale yielded 2.207 per cent of total alkaloids, which were, however, amorphous. The total alkaloid has not yet been investigated further.

A. heterophyllum (Wall), Atis root, is a plant growing in the Western temperate Himalayas. This species does not contain Aconitine and is said to be non-poisonous. Its chief constituent is an intensely bitter alkaloid - Atisine - possessing tonic and antiperiodic principles. A. palmatum, of Indian origin, yields a similar alkaloid, Palmatisine.

The province of Szechwen in West China grows large quantities of medicinal plants, among them A. Wilsoni, which is worth about 4s. per cwt., of which 55,000 lb. a year can be produced in this province; A. Fischeri, about four times the price, of which rather less are yearly available, and A. Hemsleyan, about the same price as the latter, of which about 27,000 lb. are available in an average year.

---Other Species---The Anthora, or Wholesome Aconite described by Culpepper, is a small plant about a foot high, with pale, divided green leaves, and yellow flowers - a native of the Alps. Its stem is erect, firm, angular and hairy; the leaves alternate and much cut into. The flowers are large, hooded with fragrant scent, growing on top of the branches in spikes of a pale yellow colour, smaller than the ordinary Monkshood and succeeded by five horn-like, pointed pods, or achenes, containing five angular seeds. It flowers in July and the seeds ripen at the end of August. The root is tuberous.

Culpepper tells us that the herb was used in his time, but not often. It was reputed to be very serviceable against vegetable poisons and 'a decoction of the root is a good lotion to wash the parts bitten by venomous creatures.' . . . 'The leaves, if rubbed on the skin will irritate and cause soreness and the pollen is also dangerous if blown in the eyes .'

As a matter of fact, this species of Aconite by no means deserves its reputation of harmlessness, for it is only poisonous in a less degree than the rest of the same genus, and the theory that it is a remedy against poison, particularly that of the other Aconites, is now an exploded one.

Parkinson, speaking of the Yellow Monkshood, calls it:

'The "counter-poison monkeshood" - the roots of which are effectual, not only against the poison of the poisonful Helmet Flower and all others of that kind, but also against the poison of all venomous beasts, the plague or pestilence and other infectious diseases, which raise spots, pockes, or markes in the outward skin, by expelling the poison from within and defending the heart as a most sovereign cordial.'

The so-called Winter Aconite, Aeranthis hyemalis, is not a true Aconite, though closely allied, being also a member of the Buttercup family, whose blossoms it more nearly resembles.

(a)Tincture Q: =	Drug Strength 1/10
Aconitum, moist magma containing solids	100gm.
Plant moisture 350 Cc.	= 450
Strong alcohol	683 Cc.
To make one thousand cubic centimeters of tincture.

(b) Dilutions: 2x to contain one part tincture, two parts distilled water, seven parts alcohol; 3x and higher with dispensing alcohol.

Sabadilla

Botanical: Veratrum sabadilla
Family: N.O. Liliaceae

Description
Constituents
Medicinal Action and Uses
Dosage
Poisonous, if any, with Antidotes

---Synonyms---Cevadilla. Schoenocaulon officinale. Melanthium sabadilla. Veratrum officinale. Helonias officinalis. Sabadilla officinarum. Asagraea officinalis. Sabadillermer.
---Parts Used---Seeds, dried fruit.
---Habitat---Southern North America, Guatemala and Venezuela.

---Description---The name Schcenocaulon indicates the habit of the scape, meaning 'a rush' and 'a stem.' The name Asagrcea commemorates Professor Asa Gray of Harvard University, the most distinguished of living American botanists. It is not quite certain whether the seeds are obtained from the Veratrum Sabadilla, a plant 3 or 4 feet high, or from the V. officinale, differing slightly in appearance and construction. The seeds are black, shining, flat, shrivelled and winged, odourless, with a bitter, acrid, persistent and disagreeable taste, the pale grey, amorphous powder being errhine and violently sternutatory. The seeds were known in Europe as early as 1752, but officially only as the source of veratrine.

---Constituents---Sabadilla contains several alkaloids, the most important being Cevadine, yielding cevine on hydrolysis; Veratrine, obtained from the syrupy liquor from which the cevadine has crystallized; and Cevadilline or Sabadillie, obtained after the extraction of the veratrine with ether.]

Two other alkaloids have been isolated: Sabadine, which is less sternutatory than veratrine, and Sabadinine, which is not sternutatory. Sabadilla yields about 0.3 per cent of veratrine. The seeds also contain veratric acid, cevadic acid, fat and resin.

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---Medicinal Action and Uses---Sabadilla, or cevadilla, is an acrid, drastic emeto-cathartic, in overdoses capable of producing fatal results. Cevine was found to be less poisonous than cevadine, though producing similar symptoms. The powdered seeds have been used as a vermifuge, and to destroy vermin in the hair, being the principal ingredient of the pulvis capucinorum used in Europe. Cevadilla was formerly used internally as an anthelmintic, and in rheumatic and neuralgic affections. The highly poisonous veratria, which is derived from it, has been given in minute doses internally in acute rheumatism and gout, and in some inflammatory diseases, but it must be used with caution. Veratria is useful as an ointment in rheumatism and neuralgia, but is regarded as being less valuable than aconite. The ointment is also employed for the destruction of pedicule. Applied to unbroken skin it produces tingling and numbness, followed by coldness and anaesthesia. Given subcutaneously, it causes violent pain and irritation, in addition to the symptoms following an internal dose. The principal reason against its internal use is its powerful action on the heart, the contractions of the organ becoming fewer and longer until the heart stops in systole.